study of polymorphism of the drd2 gene (-141c ins/del, rs1799732) with attention deficit hyperactivity disorder a population sample of children in iranian-azeri

backgroundattention deficit hyperactivity disorder (adhd), is a multifactorial disorder and converging evidence has implicated abnormalities of dopamine neurotransmission. the aim of this study was to examine the association of -141 polymorphisms in drd2 gene with adha among iranian-azeri population.materials and methods a case–control association study included 153 patients with attention deficit hyper activity disorder (case group), and 133 healthy subjects (control group). genomic dna was extracted peripheral blood samples by salting-out method. single nucleotide polymorphism (snp) genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism (pcr-rflp) technique. the data analysis was performed through chi-square, with a significance level of 0.05.results: there was not significant difference in the allele and genotype frequencies between adhd and -141c ins/del polymorphism in cases and controls (p>0.05). ins/ins homozygous dominants were more frequent in control group than the case group, but there was not significant difference observed (p>0.05). del/del homozygous dominants were not observed. no significant difference was detected in the allele and genotype frequencies between adhd and -141 insertion/deletion polymorphism in cases and control groups (p>0.05).conclusionour results do not detected association between the -141c ins/del, rs1799732, polymorphism and adhd disorder in population of children in iranian-azeri.